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Abstract #3111

Functional MRI and deep-brain stimulation: Impact from distortion artifacts

tefan Holiga 1 , Karsten Mueller 1 , Duan Urgok 2 , Robert Jech 3 , and Harald E. Mller 1

1 Nuclear Magnetic Resonance Unit, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2 Department of Radiation and Stereotactic Neurosurgery, Na Homolce Hospital, Prague, Czech Republic, 3 Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague, Czech Republic

Deep-brain stimulation (DBS) is a rapidly evolving neurosurgical treatment approach for a variety of disabling neurological and psychiatric symptoms, offering a range of fundamental research questions. Several functional MRI (fMRI) studies already revealed neural correlates of its striking therapeutic benefit on patients with fully-implanted and active DBS-hardware under strictly controlled safety standards. In this work we underline the importance of adhering to rigorous data-analysis standards, too. In particular, we demonstrate the DBS-hardware-related signal distortion artifact problem empirically, present the risk of false-positive fMRI findings and accordingly call for extremely cautious means of analyzing fMRI of patients with implanted electrodes.

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