Abstract #3118
Simultaneous intracranial EEG-fMRI of a seizure
David Carmichael 1 , Umair J Chaudhary 2 , Rachel C Thornton 2 , Roman Rodionov 2 , Serge Vulliemoz 3 , Andrew W McEvoy 4 , Beate Diehl 2 , Matthew C Walker 2 , John S Duncan 2 , and Louis Lemieux 2
1
Imaging and Biophysics, UCL Institute of
Child Health, London, United Kingdom,
2
UCL
Institute of Neurology, London, United Kingdom,
3
EEG
and Epilepsy Unit, University Hospital and Functional
Brain Mapping Lab, Geneva, Switzerland,
4
Victor
Horsley Department of Surgery, National Hospital for
Neurology and Neurosurgery, London, United Kingdom
We used the recently developed method of combined
intracranial EEG and fMRI (icEEG-fMRI) in a patient with
epilepsy who had a focal electrographic seizure during
scanning. We used an expert visually coded model and a
quantitative model of spectral dynamics during the
seizure obtained by frequency transformation followed by
convolution by a haemodynamic response function and
principle component analysis (PCA). Both models gave a
similar widespread network of changes including in the
right temporal lobe where the seizure onset was
recorded. The quantitative model had greater statistical
power and included a cluster proximal to the electrode
that recorded seizure onset.
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