In vivo quantification of myowater anatomical compartmentation with proton T2-relaxation studies using a three site two exchange (3S2X) model

Confirmation of the anatomical compartmentation theory to explain the biexponential T2-relaxation of bulk-water in skeletal muscle is motivated by the great clinical interest on a non-invasive tool for quantification of myowater distribution in vivo. In vivo T2-relaxation data were acquired from the soleus of healthy volunteers at different vascular filling conditions (vascular-draining, normal and vascular-filling). Variations on T2-spectra following the different vascular conditions offered strong evidences in favour of the anatomical compartmentation theory. Data were analysed by means of compartmental exchange analysis. A 3S2X model has been shown to be capable of predicting NMR relaxation data for realistic transmembrane exchange values.

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