Abstract #3128
Regularized, Joint Estimation of T 1 and M 0 Maps
Gopal Nataraj 1 , Jon-Fredrik Nielson 2,3 , and Jeffrey A. Fessler 1,2
1
Electrical Engineering and Computer Science,
University of Michigan, Ann Arbor, MI: Michigan, United
States,
2
Biomedical
Engineering, University of Michigan, Ann Arbor, MI:
Michigan, United States,
3
Functional
MRI Laboratory, University of Michigan, Ann Arbor, MI:
Michigan, United States
We have developed a model-based approach for joint
reconstruction of spin-lattice relaxation time
T
1
and
proton density
M
0
maps
from DESPOT1 sequences. Our statistical methods employ
regularization to reduce noise amplification issues
common in conventional least-squares estimators. The
proposed technique dramatically improves mapping
precision and quality, both for synthetic and
in
vivo
data,
and at a wide range of noise thresholds and flip angle
combinations.
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