Abstract #3145
Multi-Component Fitting of T 2 * Relaxation in White Matter at 3 and 7 Tesla
Erika P. Raven 1 , Peter van Gelderen 2 , Xiaozhen Li 2 , Jacco A. de Zwart 2 , John VanMeter 3,4 , and Jeff H. Duyn 2
1
Neuroscience, Georgetown University,
Washington, DC, United States,
2
Advanced
MRI section, LFMI, NINDS, National Institutes of Health,
Bethesda, MD, United States,
3
Neurology,
Georgetown University, Washington, DC, United States,
4
Georgetown
Center for Functional and Molecular Imaging, Washington,
DC, United States
Previous studies have demonstrated separation of
cellular compartments by utilizing large, local
frequency shifts (Δf) and increased T
2
*
relaxation
at high magnetic field strength (7 T). This abstract
examines the reproducibility of a multi-component
fitting model at 7 T, while also investigating the
feasibility of this method at 3 T. Our findings suggest
the possibility of separating cellular specific
contributions in white matter at both 3 and 7 T.
Quantification of cellular compartments, importantly the
myelin-water fraction, has important implications for
the study of normal aging and disease.
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