Indirect MRI Detection of Myelin Water Based on Water Exchange Properties
Xu Jiang 1 , Peter van Gelderen 1 , Jacco A de Zwart 1 , and Jeff H Duyn 1
AMRI, LFMI, NINDS, National Institutes of
Health, Bethesda, MD, United States
A novel approach is presented to indirectly image brain
myelin content. The proposed method is based on a pulsed
saturation transfer experiment, in which water with
myelin water) is selectively saturated, after which the
delayed effect on long T
is studied. Experiments performed at 7T confirm
sensitivity and specificity of the method.
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