Abstract #3166

Indirect MRI Detection of Myelin Water Based on Water Exchange Properties

Xu Jiang ¹ , Peter van Gelderen ¹ , Jacco A de Zwart ¹ , and Jeff H Duyn ¹

¹ AMRI, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States

A novel approach is presented to indirectly image brain myelin content. The proposed method is based on a pulsed saturation transfer experiment, in which water with short T ₂ (including myelin water) is selectively saturated, after which the delayed effect on long T ₂ water is studied. Experiments performed at 7T confirm sensitivity and specificity of the method.

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