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Abstract #3177

Improving Accuracy of Quantitative Susceptibility Mapping Using Edge-Weighted L1 Regularisation

Meng-Chi Hsieh 1,2 , Chung-Ming Chen 3 , Kun-Hsien Chou 4 , Ai-Ling Hsu 1,2 , Ching-Po Lin 4 , and Jyh-Horng Chen 1,2

1 Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, 2 Interdisciplinary MRI/MRS Laboratory, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, 3 Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 4 Brain Connectivity Lab, Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan

The purpose of this study is to improve accuracy for quantitative susceptibility map (QSM) by Edge-Weighted L1 (EW-L1) regularization. Numerical simulation and human brain experiment were performed to demonstrate the superiority of EW-L1 over conventional L1 method. Our results showed that EW-L1 provides highly accurate estimation and suppressed streaking artefact of QSM. Preliminary results of brain imaging suggested its feasibility of QSM in clinical practice.

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