Abstract #3205
Rapid Dynamic Temperature / T 1 / T 2 * Assessment: A Method With Potential For Monitoring Drug Delivery.
Cyril Lorenzato 1 , Chris Oerlemans 1 , Baudouin Denis de Senneville 1,2 , Chrit Moonen 1 , and Clemens Bos 1
1
Imaging Division, University Medical Center
Utrecht, Utrecht, Netherlands,
2
UMR
5251 CNRS / Universit Bordeaux 1 / INRIA, Institut de
Mathmatiques de Bordeaux, Talence, France
Thermosensitive liposomes (TSL) can be prepared to
contain drugs as well as paramagnetic MR-contrast
agents. This would allow heat induced local drug
release, while detecting the release by imaging
relaxivity changes. A method is presented to measure T
1
,
T
2
* and temperature simultaneously and is
applied to monitor release from gadolinium containing
TSL during heating. The results indicated the need to
correct for temperature related apparent proton density
changes in the T1 measurements. The method will be an
aid to monitor the release of MR-contrast agents from
TSL in local drug delivery studies, as a correlate of
drug release.
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