Simultaneous Whole-Brain T 1 and Flip Angle Mapping with MP3RAGE

The MP3RAGE sequence is a straightforward modification of MP2RAGE that acquires three images with different T ₁ contrast following an inversion pulse. These images can be used for direct T ₁ lookup, enabling accurate high-resolution mapping in clinically relevant scan times (10 minutes or less). We demonstrate that, with an appropriate choice of parameters, MP3RAGE T ₁ maps can be made almost totally insensitive to B ₁ effects, a key requirement for high-field imaging. These T ₁ maps have excellent accuracy compared to a reference map. The MP3RAGE data can also be used to generate a whole-brain flip angle map at the same resolution.

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