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Abstract #3219

Quantitative T2* MRI for bone marrow iron overload assessment in a large cohort of thalassemia major patients.

Antonella Meloni 1 , Gennaro Restaino 2 , Gianluca Valeri 3 , Massimiliano Missere 2 , Vincenzo Positano 1 , Stefano Pulini 4 , Michele Centra 5 , Massimo Lombardi 1 , and Alessia Pepe 1

1 CMR Unit, Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology, Pisa, Italy, 2 Dipartimento di Radiologia, Un. Cattolica del Sacro Cuore - Centro di Ricerca e Formazione ad Alta Tecnologia "G. Paolo II", Campobasso, Italy, 3 Dipartimento di Radiologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy, 4 U.O. Ematologia Clinica, Osped. Civile Spirito Santo, Pescara, Italy, 5 Servizio Trasfusionale, OO.RR. Foggia, Foggia, Italy

The bone marrow contains reticuloendothelial cells and, of consequence, it is among the first organs to be affected by iron overload, which can be non-invasively assessed by MRI T2* technique. In thalassemia major patients bone marrow T2* values increased with age. Males showed significantly higher T2* values. Bone marrow T2* values were associated with heart, liver and spleen T2* values. Splenectomised patients showed higher bone marrow T2* values.

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