Abstract #3219
Quantitative T2* MRI for bone marrow iron overload assessment in a large cohort of thalassemia major patients.
Antonella Meloni 1 , Gennaro Restaino 2 , Gianluca Valeri 3 , Massimiliano Missere 2 , Vincenzo Positano 1 , Stefano Pulini 4 , Michele Centra 5 , Massimo Lombardi 1 , and Alessia Pepe 1
1
CMR Unit, Fondazione G.Monasterio
CNR-Regione Toscana and Institute of Clinical
Physiology, Pisa, Italy,
2
Dipartimento
di Radiologia, Un. Cattolica del Sacro Cuore - Centro di
Ricerca e Formazione ad Alta Tecnologia "G. Paolo II",
Campobasso, Italy,
3
Dipartimento
di Radiologia, Azienda Ospedaliero-Universitaria
Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona,
Italy,
4
U.O.
Ematologia Clinica, Osped. Civile Spirito Santo,
Pescara, Italy,
5
Servizio
Trasfusionale, OO.RR. Foggia, Foggia, Italy
The bone marrow contains reticuloendothelial cells and,
of consequence, it is among the first organs to be
affected by iron overload, which can be non-invasively
assessed by MRI T2* technique. In thalassemia major
patients bone marrow T2* values increased with age.
Males showed significantly higher T2* values. Bone
marrow T2* values were associated with heart, liver and
spleen T2* values. Splenectomised patients showed higher
bone marrow T2* values.
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