Prediction of Complex MR Signals of a Single Vein: Potential Advancement to Measurement of Venous Oxygen Saturation and Diameter
Sung-Hong Park 1 and Seong-Gi Kim 2,3
Bio and Brain Engineering, Korea Advanced
Institute of Science and Technology, Daejeon, Daejeon,
University of Pittsburgh, Pittsburgh, PA, United States,
for Neuroscience Imaging Research, Institute for Basic
Science (IBS), Dept. of Biological Sciences, SKKU,
We proposed a new approach to simultaneous measurement
of oxygen saturation levels and diameter of a single
intracortical vein of rat brain at 9.4T. The method is
based on minimization of error between complex MR
signals from experiments and simulations. It does not
limit physical angle or location of veins. The
MION-based phantom study showed measured susceptibility
and diameter within 10% of error, whereas in vivo oxygen
saturation levels and diameters were over-estimated.
Visually the complex signal distributions from the
experiment and simulations were very close to each
other. The method is promising but requires further
studies to improve accuracy.
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