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Abstract #3255

Prediction of Complex MR Signals of a Single Vein: Potential Advancement to Measurement of Venous Oxygen Saturation and Diameter

Sung-Hong Park 1 and Seong-Gi Kim 2,3

1 Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Daejeon, Korea, 2 Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 3 Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Dept. of Biological Sciences, SKKU, Suwon, Korea

We proposed a new approach to simultaneous measurement of oxygen saturation levels and diameter of a single intracortical vein of rat brain at 9.4T. The method is based on minimization of error between complex MR signals from experiments and simulations. It does not limit physical angle or location of veins. The MION-based phantom study showed measured susceptibility and diameter within 10% of error, whereas in vivo oxygen saturation levels and diameters were over-estimated. Visually the complex signal distributions from the experiment and simulations were very close to each other. The method is promising but requires further studies to improve accuracy.

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