Abstract #3258
Removal of Arterial Vessels Contribution for Improved Quantification of Normalized Venous Volume in Patients with Sickle Cell Disease
Adam M Winchell 1,2 , Ruitian Song 1 , Ralf B Loeffler 1 , Winfred Wang 3 , Jane Hankins 3 , Kathleen J Helton 1 , and Claudia M Hillenbrand 1
1
Radiological Sciences, St. Jude Childrens
Research Hospital, Memphis, TN, United States,
2
Biomedical
Engineering, University of Memphis, Memphis, TN, United
States,
3
Hematology,
St. Jude Childrens Research Hospital, Memphis, TN,
United States
The most devastating complication in children with
sickle cell disease (SCD) is stroke.
Susceptibility-weighted imaging (SWI) with MR
angiography can be used to investigate the integrity of
the venous and arterial cerebrovascular system. However,
some irregular or tortuous arteries also appearing
hypointense due to failure of flow compensation in GRE
sequence have been reported in SCD patients. The mixture
of decreased venous conspicuity and arterial vessels
could lead to misinterpretation or concealment of venous
vasculature abnormalities. In this study, we propose a
post-processing technique to remove arterial vessel
contamination in SWI exams.
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