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Abstract #3258

Removal of Arterial Vessels Contribution for Improved Quantification of Normalized Venous Volume in Patients with Sickle Cell Disease

Adam M Winchell 1,2 , Ruitian Song 1 , Ralf B Loeffler 1 , Winfred Wang 3 , Jane Hankins 3 , Kathleen J Helton 1 , and Claudia M Hillenbrand 1

1 Radiological Sciences, St. Jude Childrens Research Hospital, Memphis, TN, United States, 2 Biomedical Engineering, University of Memphis, Memphis, TN, United States, 3 Hematology, St. Jude Childrens Research Hospital, Memphis, TN, United States

The most devastating complication in children with sickle cell disease (SCD) is stroke. Susceptibility-weighted imaging (SWI) with MR angiography can be used to investigate the integrity of the venous and arterial cerebrovascular system. However, some irregular or tortuous arteries also appearing hypointense due to failure of flow compensation in GRE sequence have been reported in SCD patients. The mixture of decreased venous conspicuity and arterial vessels could lead to misinterpretation or concealment of venous vasculature abnormalities. In this study, we propose a post-processing technique to remove arterial vessel contamination in SWI exams.

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