Observation of regional variations of conductivity in in-vivo human brain

Electrical conductivity of human brain tissue reveals tissue properties such as ion concentration, micro-structure and temperature. Due to these relationships between electrical conductivity value and biological factors, electrical conductivity has a potential to be a powerful bio-marker. Recently, in brain area, magnetic resonance electrical property tomography (MREPT) has been researched for clinical applications (systematic brain tumor) and biological characteristics (ion concentration and pH). However, due to lack of SNR and systemic error on tissue boundary, there were some restricts to quantify the electrical conductivity of sub-divisional brain tissue. Therefore, in this study, we try to observe conductivity values of sub-divisional brain tissue using weighted polynomial fitting technique with adaptively generated weighting factor. The weighting factor was generated using MPRAGE image that is well-optimized to enhance brain tissue contrast.

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