Abstract #3287
Magnetic susceptibilities of iron rich gray matter nuclei are negatively correlated with various brain functions in healthy adults
Wei Li 1,2 , Christian Langkammer 3 , Katja Petrovic 3 , Reinhold Schmidt 3 , Allen W Song 1,4 , Stefan Ropele 3 , and Chunlei Liu 1,4
1
Brain Imaging and Analysis Center, Duke
University, Durham, NC, United States,
2
Research
Imaging Institute, University of Texas Health Science
Center at San Antonio, San Antonio, TX, United States,
3
Neurology,
Medical University of Graz, Graz, Austria,
4
Radiology,
Duke University, Durham, NC, United States
In human brain, certain deep gray matter structures,
particularly globus pallidus, putamen, caudate nucleus,
substantia nigra, red nucleus, and dentate nucleus have
especially high iron contents compared to other brain
tissues. In this study, we correlated the magnetic
susceptibility a surrogate marker of brain iron of
these gray matter structures with several clinical
measures of brain function in 135 healthy adults aged
40~83 years. We observed significant negative
correlations between the scores of motor function,
language skills, transit memory, and executive functions
with the magnetic susceptibility of one or several of
the aforementioned deep brain structures.
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