Abstract #3298
Simulating variable RF power pre-saturation schemes to enhance CEST contrast for exchangeable protons near 1.0 ppm
Daniel James Clark 1,2 , Seth A Smith 3,4 , and Michael V Knopp 1
1
Wright Center of Innovation, Department of
Radiology, The Ohio State University, Columbus, OH,
United States,
2
Departmemt
of Biomedical Engineering, The Ohio State University,
Columbus, OH, United States,
3
Vanderbilt
University Institute of Imaging Science,Department of
Radiology and Radiological Sciences, Vanderbilt
University, Nashville, TN, United States,
4
Department
of Biomedical Engineering, Vanderbilt University,
Nashville, TN, United States
In CEST MRI sensitivity to hydroxyl protons is difficult
because of small chemical shifts and fast exchange
rates, most evident on clinical scanners where the
spectral separation is less and the signal is confounded
by magnetization transfer and direct water saturation.
We propose a novel, variable RF power pre-saturation
scheme and present simulations which show that such a
scheme can flatten the direct water saturation component
of the z-spectrum curve, enhancing CEST contrast from
hydroxyl moieties (1 ppm). We further examine the impact
of the variable saturation scheme in the presence of
concomitant MT and DWS effects.
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