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Abstract #3298

Simulating variable RF power pre-saturation schemes to enhance CEST contrast for exchangeable protons near 1.0 ppm

Daniel James Clark 1,2 , Seth A Smith 3,4 , and Michael V Knopp 1

1 Wright Center of Innovation, Department of Radiology, The Ohio State University, Columbus, OH, United States, 2 Departmemt of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, 3 Vanderbilt University Institute of Imaging Science,Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 4 Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

In CEST MRI sensitivity to hydroxyl protons is difficult because of small chemical shifts and fast exchange rates, most evident on clinical scanners where the spectral separation is less and the signal is confounded by magnetization transfer and direct water saturation. We propose a novel, variable RF power pre-saturation scheme and present simulations which show that such a scheme can flatten the direct water saturation component of the z-spectrum curve, enhancing CEST contrast from hydroxyl moieties (1 ppm). We further examine the impact of the variable saturation scheme in the presence of concomitant MT and DWS effects.

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