Abstract #3332
Selective Myelin Water Suppression by Direct Saturation
Xu Jiang 1,2 , Peter van Gelderen 1 , Jacco A de Zwart 1 , and Jeff H Duyn 1
1
AMRI, LFMRI, NINDS, National Institutes of
Health, Bethesda, MD, United States,
2
Department
of Physics, University of Maryland, College Park, MD,
United States
The effectiveness of using adiabatic, on resonance, 3600
pulses for myelin water imaging based on pulsed
saturation transfer contrast is evaluated. Using
multi-component analysis of T2* signal decay at 7T, we
demonstrate that adiabatic, on-resonance, 3600 pulses
allow a strong (80%) saturation of myelin water, while
effects on axonal and interstitial water can be kept
below 25%. This high selectivity greatly facilitated
saturation transfer kinetics and the visualization of
myelin water content.
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