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Abstract #3332

Selective Myelin Water Suppression by Direct Saturation

Xu Jiang 1,2 , Peter van Gelderen 1 , Jacco A de Zwart 1 , and Jeff H Duyn 1

1 AMRI, LFMRI, NINDS, National Institutes of Health, Bethesda, MD, United States, 2 Department of Physics, University of Maryland, College Park, MD, United States

The effectiveness of using adiabatic, on resonance, 3600 pulses for myelin water imaging based on pulsed saturation transfer contrast is evaluated. Using multi-component analysis of T2* signal decay at 7T, we demonstrate that adiabatic, on-resonance, 3600 pulses allow a strong (80%) saturation of myelin water, while effects on axonal and interstitial water can be kept below 25%. This high selectivity greatly facilitated saturation transfer kinetics and the visualization of myelin water content.

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