Abstract #3346
Case Study: 2D L-COSY of Low-Grade Gliomas at 7T
Gaurav Verma 1 , Suyash Mohan 1 , Steven Brem 2 , Michael Albert Thomas 3 , and Harish Poptani 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
Neurosurgery,
University of Pennsylvania, Philadelphia, PA, United
States,
3
Radiological Sciences, University of
California Los Angeles, Los Angeles, CA, United States
Two-dimensional (2D) localized correlated spectroscopy
(L-COSY) at 7T offers additional spectral separation
than is available with conventional sequences or at
lower fields. This additional separation could
facilitate the unambiguous quantification of
ethanolamine, phosphocholine (PC), glycerophosphocholine
(GPC), phosphoethanolamine (PE),
glycerophosphoethanolamine (GPE) and lactate
metabolites whose presence has shown correlation with
tumor. 2D L-COSY was acquired in two patients with
low-grade gliomas. Resulting spectra showed
clearly-defined cross peaks lactate and choline-containing
compounds. L-COSY could have clinical utility in
detecting biochemical changes in brain tumor and
potentially resolving high and low grade tumor and
healthy tissue.
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