Abstract #3349
Metabolomic Predictors of Malignancy in IDH-mutant Gliomas using 1 H High Resolution Magic Angle Spinning Magnetic Resonance Spectroscopy
Franziska Loebel 1,2 , Leo L. Cheng 2,3 , Emily A. Decelle 2,3 , Andrew S. Chi 4 , Daniel P. Cahill 1 , and Ovidiu C. Andronesi 2
1
Department of Neurosurgery, Massachusetts
General Hospital / Harvard Medical School, Boston, MA,
United States,
2
Martinos
Center for Biomedical Imaging, Massachusetts General
Hospital / Harvard Medical School, Boston, MA, United
States,
3
Department
of Radiopathology, Massachusetts General Hospital /
Harvard Medical School, Boston, MA, United States,
4
Department
of Neurology, Massachusetts General Hospital/Harvard
Medical School, Boston, MA, United States
The present study aimed at identifying metabolomic
predictors of malignancy in IDH-mutant gliomas, using
ex-vivo High-Resolution Magic Angle Spinning Magnetic
Resonance Spectroscopy (1H-HRMAS-MRS). Our results
suggest that high-grade IDH-mutant gliomas show distinct
metabolomic differences compared to low-grade cases.
1H-HRMAS-MRS has clinical applicability, yieldieng the
potential to distinguish more aggressive and malignant
IDH-mutant gliomas from indolent low-grade tumors.
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