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Abstract #3356

Volumetric Spectroscopic Imaging of GBM Radiation Treatment Volumes

Radka Stoyanova 1 , Andres Parra 1 , Fazilat Ishkanian 1 , Arnold Markoe 1 , Rakesh Gupta 2 , Bhaswati Roy 2 , and Andrew Maudsley 3

1 Radiation Oncology, University of Miami, Miami, Florida, United States, 2 Fortis Memorial Research Institute, Haryana, India, 3 Radiology, University of Miami, Miami, Florida, United States

Metabolic tumor volumes (MTV), based on volumetric Magnetic Resonance Spectroscopic Imaging (MRSI) are compared with standard radiation treatment (RT) volumes in 19 treatment naive GBM patients. In a third of these patients more than a third of the MTVs are outside of the treatment area. MTVs are constructed based on high Choline distributions which are related to active and infiltrative tumor. This is the first comprehensive evaluation of MRSI covering the entire brain. The data is integrated in RT software and may lead to the development of novel treatment strategies tailored to each patients active tumor.

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