Abstract #3356
Volumetric Spectroscopic Imaging of GBM Radiation Treatment Volumes
Radka Stoyanova 1 , Andres Parra 1 , Fazilat Ishkanian 1 , Arnold Markoe 1 , Rakesh Gupta 2 , Bhaswati Roy 2 , and Andrew Maudsley 3
1
Radiation Oncology, University of Miami,
Miami, Florida, United States,
2
Fortis
Memorial Research Institute, Haryana, India,
3
Radiology,
University of Miami, Miami, Florida, United States
Metabolic tumor volumes (MTV), based on volumetric
Magnetic Resonance Spectroscopic Imaging (MRSI) are
compared with standard radiation treatment (RT) volumes
in 19 treatment naive GBM patients. In a third of these
patients more than a third of the MTVs are outside of
the treatment area. MTVs are constructed based on high
Choline distributions which are related to active and
infiltrative tumor. This is the first comprehensive
evaluation of MRSI covering the entire brain. The data
is integrated in RT software and may lead to the
development of novel treatment strategies tailored to
each patients active tumor.
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