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Abstract #3359

Neuroanatomy Reveals Radiation-Induced Memory Deficits in Mice

A. Elizabeth de Guzman 1,2 , Benjamin Turnbull 1 , Rebecca Crosier 1 , and Brian J. Nieman 1,2

1 Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada, 2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

Therapeutic cranial irradiation for pediatric patients often results in long term cognitive side effects, such as memory loss. Using anatomical analysis, we identified a correlation between memory function, as determined by the novel object test, and a subset of brain structures in the young irradiated mouse. Structures identified are those previously shown to be important in novel object recognition, demonstrating the potential for neuroanatomy to act as a marker of cognitive deficit in the described mouse model.

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