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Abstract #3370

Equilibrium Model for Magnetic Resonance Grading of Hippocampal Sclerosis in Temporal Lobe Epilepsy

Hassan Bagher-Ebadian 1,2 , Mohammad Reza Nazem-Zadeh 1 , Jason M Schawlb 3 , Abdelrahman Hassane 1 , and Hamid Soltanian-Zadeh 1,4

1 Radiology, Henry Ford Hospital, Detroit, MI, United States, 2 Physics, Oakland University, Rochester, MI, United States, 3 Neurosurgery, Henry Ford Hospital, MI, United States, 4 CIPCE, ECE Dept., University of Tehran, Tehran, Iran

Temporal lobe epilepsy (TLE) patients that are medically refractory may be candidates for surgical intervention. It is critical to select the surgery candidates confidently to maximize the chance of post-surgical-seizure freedom. The presence of sclerosis in hippocampus is a good indicator for a positive outcome of surgery. This study introduces a novel approach (Equilibrium-Model) as a grader of sclerosis severity in hippocampus using MR-Fluid Attenuation Inversion Recovery (MR-FLAIR) information. The proposed method is applied on MR-FLAIR information of ten TLE patients with hippocampal sclerosis (pathology-proven). Results (80% correct-classification-fraction) imply that the proposed method may increase confidence in localizing seizure focus.

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