Imaging the Cortical Myelination Pattern and Its Correlation with Clinical Disability in Multiple Sclerosis
Katherine L Pogrebniak 1,2 , Ziad S Saad 3 , Daniel S Reich 1 , and Govind Nair 1
NINDS, National Institutes of Health,
Bethesda, MD, United States,
University, Princeton, NJ, United States,
National Institutes of Health, Bethesda, MD, United
Cortical myelin is extensively lost in advanced MS and
and is thought to be a major cause of disability.
Several studies have characterized myelin content of the
cortical gray matter using optimized T1-weighted MPRAGE
and ratio of T1- over T2-weighted images. In this study
of 5 healthy volunteers and 11 MS patients, T1/T2 signal
trended to be lower in the cortical ribbon of MS cases
vs. healthy volunteers, and this signal change
correlated with clinical measures of disability
including time required to complete a 9-hole peg test.
The technique shows potential as a quantitative marker
for cortical demyelination.
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