Abstract #3375
Imaging the Cortical Myelination Pattern and Its Correlation with Clinical Disability in Multiple Sclerosis
Katherine L Pogrebniak 1,2 , Ziad S Saad 3 , Daniel S Reich 1 , and Govind Nair 1
1
NINDS, National Institutes of Health,
Bethesda, MD, United States,
2
Princeton
University, Princeton, NJ, United States,
3
NIMH,
National Institutes of Health, Bethesda, MD, United
States
Cortical myelin is extensively lost in advanced MS and
and is thought to be a major cause of disability.
Several studies have characterized myelin content of the
cortical gray matter using optimized T1-weighted MPRAGE
and ratio of T1- over T2-weighted images. In this study
of 5 healthy volunteers and 11 MS patients, T1/T2 signal
trended to be lower in the cortical ribbon of MS cases
vs. healthy volunteers, and this signal change
correlated with clinical measures of disability
including time required to complete a 9-hole peg test.
The technique shows potential as a quantitative marker
for cortical demyelination.
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