Longitudinal Imaging of Cerebral Microhemorrhages Using Qualitative and Quantitative Susceptibility Imaging in Military Service Members with Traumatic Brain Injury
Wei Liu 1,2 , Karl Soderlund 3 , Tian Liu 4 , Justin S. Senseney 1,2 , Ping-Hong Yeh 1,2 , John Graner 1,2 , John Ollinger 1,2 , Jamie Harper 1,2 , David Joy 1,2 , Terrance R. Oakes 1,2 , Yi Wang 4 , and Gerard Riedy 1,2
National Intrepid Center of Excellence,
Bethesda, Maryland, United States,
Capital Neuroimaging Consortium, Bethesda, Maryland,
Reed National Military Medical Center, Bethesda,
Maryland, United States,
Engineering, Cornell University, New York, New York,
Cerebral microhemorrhages in combat-related TBI patients
were characterized longitudinally using SWI and QSM.
Both approaches demonstrated better conspicuity on
majorities of the detected microhemorrhages relative to
GRE. QSM demonstrated worse conspicuity than GRE in a
small portion of the microhemorrhages. Both SWI and QSM
showed strong trends to detect more microhemorrhages at
baseline compared to follow-ups in TBI patients. For
individual microhemorrhages, both the size of
microhemorrhage and total magnetic susceptibility
decreased significantly from baseline to follow-up
scans, suggesting a continued subtle evolution of the
hemosiderin blood products on a longer time frame than
was previously believed.
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