A Diffusion Tensor MRI Study of Pediatric patients with Severe Non-Traumatic Brain Injury
Elisabetta Pagani 1 , Maria A. Rocca 1 , Erika Molteni 2 , Sandra Strazzer 2 , Giacomo Boffa 1 , Monica Recla 2 , Susanna Galbiati 2 , Alessandra Bardoni 2 , Giancarlo Comi 3 , and Massimo Filippi 1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
Sci. Inst. IRCCS E. Medea, Bosisio
Parini, LC, Italy,
of Neurology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy
We obtained diffusion tensor MRI scans from 16 children
with severe disorders of consciousness due to
non-traumatic origin and 31 controls. Measures of
fractional anisotropy (FA) and diffusivity of the corpus
callosum (CC) and cerebellar peduncles (CP) differed
significantly between patients and controls. Fractional
anisotropy values of the superior CP correlated with the
score at the Glasgow Coma Scale, whereas FA values of
the CC correlated with the Disability Rating Scale.
These data suggest that global, rather than focal
damage, contributes to the clinical severity of children
with severe non-traumatic brain injury.
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