Abstract #3469
Coexistence of enhanced and reduced Default Mode Network functional connectivity in Autism Spectrum Disorder
Letizia Casiraghi 1,2 , Chiara Pesola 3 , Fabrizio Esposito 4,5 , Carol Di Perri 2 , and Francesco Di Salle 4,5
1
Brain and Behavioral Sciences, University of
Pavia, Pavia, Italy,
2
Brain
Connectivity Center, IRCCS C. Mondino, Pavia, Italy,
3
Department
of Pediatrics and Child Neuropsychiatry, Sapienza
University of Rome, Rome, Italy,
4
Department
of Medicine and Surgery, University of Salerno,
Baronissi (SA), Italy,
5
Department of
Cognitive Neuroscience, Maastricht University,
Maastricht, Netherlands
Autism Spectrum Disorder (ASD) is a neurodevelopmental
disability with early onset and variable developmental
trajectory. Nowadays a standard pattern of resting state
Functional Connectivity (FC) alteration in ASD is not
defined. We used ICA analysis on ASD and tipically
developing subjects in order to test the influence of
methodological choices on results and to investigate the
differences in FC focusing on the Default Mode Network
(DMN). Our study outlines the presence of both hypo- and
hyper- FC within the DMN in ASD children.
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