Abstract #3523
A Comparison Study of Imaging CBF Change in Transient MCAO Rat Brain with the SR-T 1 Method and the CASL Technique
Xiao Wang 1 , Afshin A Divani 2 , Yi Zhang 1 , Wei Chen 1 , and Xiao-Hong Zhu 1
1
Center for Magnetic Resonance Research,
Department of Radiology, University of Minnesota Medical
School, Minneapolis, Minnesota, United States,
2
Neurology,
University of Minnesota, Minnesota, United States
The SR-T1 method of imaging CBF change has previously
validated with the Laser Doppler flowmetry measurement,
the continuous arterial spin labeling (CASL) technique
and at different field strength in either normal or
global four-vessel occlusion rat model. In the present
study, the SR-T1 method is further verified with the
CASL technique in the preclinical unilateral MCAO rat
brain. The results reveal that both the SR-T1 method and
the CASL technique are sensitive to the impaired
vascular response subsequent to the ischemic attack
induced by MCA occlusion. There is an excellent
agreement of the CBF change values in different ROIs and
spatial pattern in the delta CBF images measured with
the SR-T1 method and the CASL technique. Therefore, the
SR-T1 method provides a robust, noninvasive and reliable
tool to image CBF change in an absolute scale induced by
physiological and pathological conditions associated
with cerebrovascular diseases.
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