Abstract #3537
Enhanced 129Xe Hyper-CEST Efficiency Using PK11195 Functionalized Cryptophane-A
Krista M. Dowhos 1,2 , Matthew S. Fox 3 , Iain K. Ball 3 , Tao Li 3,4 , Gowtham Gajawada 3,4 , Jordan Wentzell 4 , Brenton DeBoef 5 , and Mitchell S. Albert 3,4
1
Lakehead University, Thunder Bay, Ontario,
Canada,
2
Thunder
Bay Regional Research Institute, Thunder Bay, Ontario,
Canada,
3
Thunder
Bay Regional Research Institute, Ontario, Canada,
4
Lakehead
University, Ontario, Canada,
5
Rhode
Island University, Rhode Island, United States
The combination of hyperpolarized 129Xe MRI and Chemical
Exchange Saturation Transfer (CEST), Hyper-CEST, can
potentially enhance MR sensitivity by 108, making it a
promising molecular imaging technique via MRI. In this
study, we employ a Hyper-CEST pulse sequence at 3T,
which uses pulsed saturation to lower SAR and provides
an unprecedented 87% depletion in 129Xe(dissolved)
signal. In addition, we used the same pulse sequence to
demonstrate Hyper-CEST imaging, which may eventually
allow for molecular imaging of inflammation sites in the
body caused by diseases such as COPD and arthritis, due
to the ability of PK11195 to target these pathologies.
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