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Abstract #3545

Comparison of AIF determination methods and gadolinium contrast agents for quantitative pulmonary perfusion

Laura Bell 1 , Kang Wang 2 , Alejandro Munoz Del Rio 3 , Thomas Grist 1,3 , Sean Fain 1,3 , and Scott Nagle 1,3

1 Medical Physics, University of Wisconsin - Madison, Madison, Wisconsin, United States, 2 Global MR Applications and Workflow, GE Healthcare, Wisconsin, United States, 3 Radiology, University of Wisconsin - Madison, Wisconsin, United States

Quantification of pulmonary perfusion using T1-weighted contrast-enhanced MRI is challenging due to both the nonlinear relationship between signal intensity (SI) and contrast agent (CA) concentration, and the inherently low signal within the lung itself. We assessed the performance of three different AIF reconstruction methods using both gadopentetate dimeglumine and gadobenate dimeglumine in 12 healthy human subjects for pulmonary blood flow (PBF) measurements. There were no observed differences in PBF between all three AIF reconsturction methods using Gd-DTPA, however there were differences using Gd-BOPTA that need to be considered within a clinical setting. Lung enhancement was improved with GD-BOPTA.

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