Abstract #3545
Comparison of AIF determination methods and gadolinium contrast agents for quantitative pulmonary perfusion
Laura Bell 1 , Kang Wang 2 , Alejandro Munoz Del Rio 3 , Thomas Grist 1,3 , Sean Fain 1,3 , and Scott Nagle 1,3
1
Medical Physics, University of Wisconsin -
Madison, Madison, Wisconsin, United States,
2
Global
MR Applications and Workflow, GE Healthcare, Wisconsin,
United States,
3
Radiology,
University of Wisconsin - Madison, Wisconsin, United
States
Quantification of pulmonary perfusion using T1-weighted
contrast-enhanced MRI is challenging due to both the
nonlinear relationship between signal intensity (SI) and
contrast agent (CA) concentration, and the inherently
low signal within the lung itself. We assessed the
performance of three different AIF reconstruction
methods using both gadopentetate dimeglumine and
gadobenate dimeglumine in 12 healthy human subjects for
pulmonary blood flow (PBF) measurements. There were no
observed differences in PBF between all three AIF
reconsturction methods using Gd-DTPA, however there were
differences using Gd-BOPTA that need to be considered
within a clinical setting. Lung enhancement was improved
with GD-BOPTA.
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