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Abstract #3558

Effect of Iodinated Contrast Medium in Diabetic Rat Kidney as Evaluated by BOLD MRI

Lu-Ping Li 1,2 , Tammy Franklin 1 , Richard Solomon 3 , and Pottumarthi V Prasad 1,2

1 Radiology, Northshore University HealthSystem, Evanston, IL, United States, 2 University of Chicago Pritzker School of Medicine, Chicago, IL, United States, 3 University of Vermont College of Medicine, VT, United States

Iodinated contrast induced acute kidney injury (CIAKI) is the third cause of hospital-acquired AKI. Diabetes is one direct risk factor. Streptozotocin (STZ) treated rat is the most common model of human diabetes. The effects of iodinated contrast were evaluated in STZ treated rats using BOLD MRI. Our preliminary data show R2* responses are much smaller than those previously observed in alternate model of CIAKI. This is probably due to the persistent hyperfiltration in this model resulting in enhanced washout of contrast medium. Future studies may be necessary to evaluate whether fluid restriction could make the responses comparable to previous models.

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