Abstract #3565
Changes in Intra-Renal Oxygenation by BOLD MRI as an Early Marker of Iodinated Contrast Induced Acute Kidney Injury
Lu-Ping Li 1,2 , Jon Thacker 1,3 , Tammy Franklin 1 , Jing Lu 2,4 , Ying Zhou 5 , Maria Papadopulou-Rosenzweig 6 , Richard Solomon 7 , and Pottumarthi V Prasad 1,2
1
Radiology, Northshore University
HealthSystem, Evanston, IL, United States,
2
University
of Chicago Pritzker School of Medicine, Chicago, IL,
United States,
3
Biomedical
Engineering, Northwestern University, Evanston, IL,
United States,
4
Obstetrics
and Gynaecology, Northshore University HealthSystem,
Evanston, IL, United States,
5
Center
for Clinical & Research Informatics, Northshore
University HealthSystem, Evanston, IL, United States,
6
Radiation
Medicine, Northshore University HealthSystem, Evanston,
IL, United States,
7
Nephrology,
University of Vermont College of Medicine, Burlington,
VT, United States
Clinical definition of iodinated contrast induced (CI)
acute kidney injury (AKI) is based on serum creatinine
measurements made 48-72 hours post-contrast
administration. Such a delay results in poor specificity
in terms of causal relationship. Novel marker urinary
neutrophil gelatinase-associated lipocalin (NGAL) has
shown response 8 hours post-contrast. Previous reports
have shown that changes in R2* by MRI can demonstrate
responses in real time with contrast administration.
Here, we evaluated the effects of interventions to
prevent CIAKI using BOLD MRI and compare them to urinary
NGAL measurements made at baseline and 4 hrs
post-contrast in a CIAKI susceptible rat model.
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