Abstract #3567
How does renal function change with nephrectomy? Initial experience using renal blood flow measured by arterial spin labelling MRI combined with 51Cr-EDTA filtration (GFR) to calculate renal filtration fraction
Marica Cutajar 1 , David L Thomas 2 , Tina Banks 3 , Christopher A Clark 1 , and Isky Gordon 1
1
Imaging and Biophysics, UCL, Institute of
Child Health, London, London, United Kingdom,
2
Department
of Brain Repair and Rehabilitation, UCL, Institute of
Neurology, London, London, United Kingdom,
3
Department
of Radiology, Great Ormond Street Hospital, London,
London, United Kingdom
This study is the first to measure renal plasma flow (RPF)
non-invasively in kidney donors before and after
donation. RPF obtained using Arterial Spin Labelling MRI
combined with 51Cr-EDTA filtration (GFR) was used to
calculate renal filtration fraction and hence assess the
effect of nephrectomy on renal function. 7 healthy
kidney transplant donors underwent two MRI scans
(without the use of exogenous contrast agents) as well
as multiple blood samples 51Cr-EDTA, prior to
nephrectomy and one year after donation. We found that
GFR increased more than RPF hence causing the FF to
increase.
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