Abstract #3610
Hypoxia accelerated metabolic alterations in the diabetic kidney assessed with hyperpolarized MRS
Christoffer Laustsen 1,2 , Sara Lycke 3 , Fredrik Palm 3,4 , Jakob Appel stergaard 5,6 , Bo Martin Bibby 7 , Rikke Nrregaard 8 , Allan Flyvbjerg 5 , Michael Pedersen 1 , and Jan Henrik Ardenkjaer-larsen 9,10
1
MR Research Centre, Department of Clinical
Medicine, Aarhus University, Aarhus, Aarhus, Denmark,
2
bDanish
Research Centre for Magnetic Resonance, Copenhagen
University Hospital Hvidovre, Hvidovre, Denmark,
3
Department
of Medical Cell Biology, Uppsala University, Uppsala,
Sweden,
4
Division of Drug Research, Department
of Medical and Health Sciences, Linkping University,
Linkping, Sweden,
5
Department
of Endocrinology and Internal Medicine, Aarhus
University, Aarhus, Denmark,
6
The
Danish Diabetes Academy, Aarhus, Denmark,
7
Department
of Biostatistics, Aarhus University, Aarhus, Denmark,
8
Department
of Clinical Medicine, Aarhus University, Aarhus,
Denmark,
9
GE
Healthcare, Broendby, Denmark,
10
Department of
Electrical Engineering, Technical University of Denmark,
Kgs. Lyngby, Denmark
We demonstrated an increased oxygen sensitivity in
kidneys of diabetic patients, using hyperpolarized [1-
13
C]pyruvate
and BOLD MRI. This finding may explain the observed
increased risk of developing nephropathy in diabetic
patients inspiring reduced oxygen (<20%). The underlying
explanation is likely explained by an acceleration of
the hyperglycemia mediated polyol pathway cascade,
leading to an overproduction of nicotinamide adenine
dinucleotide (NADH), thereby increasing the lactate
pool, while the oxidative phosphorylation is unaffected.
In parallel, we observed a correlation between the [1-
13
C]pyruvate
derivates: alanine and bicarbonate; which may
potentially be used as a sensitive marker for intrarenal
oxygen deficiency.
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