Diffusion-weighted imaging detects early progression of renal fibrosis in a murine model of unilateral ureteral obstruction

The purpose of this study was to confirm that apparent diffusion coefficient (ADC) is a reliable biomarker for the assessment of renal fibrosis in a murine model of unilateral ureteral obstruction (UUO). On day 0, group 1 had surgery for UUO, while group 2 was used as a sham group (only incision was applied). ADC and volume of kidneys were measured on days 1, 3 and 7. Relative ADC (ADC of ipsilateral side divided by ADC of contralateral side) of parenchyma differed significantly on days 3 and 7 between UUO group and control group. Our results suggest the relative ADC may serve as a reliable imaging biomarker.

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