Abstract #3615
Whole-body Imaging of Adipose Tissues in Mouse at 9.4T
Patrick J Bolan 1 , Amrutesh Puranik 2 , John W Osborn Jr. 3 , Maria Razzoli 3 , Alessandro Bartolomucci 3 , Pu Tzu Liu 4 , Yi-Wei Lin 4 , and Li-Na Wei 4
1
Radiology - CMRR, University of Minnesota,
Minneapolis, Minnesota, United States,
2
Mayo
Clinic, Rochester, MN, United States,
3
Integrative
Biology and Physiology, University of Minnesota,
Minneapolis, MN, United States,
4
Pharmacology,
University of Minnesota, Minneapolis, MN, United States
This work demonstrates anatomic and parametric water-fat
imaging of adipose tissues in post mortem mice at 9.4 T
with spatial resolution (156 m isotropic) substantially
higher than previous studies. Anatomic and fat fraction
images were used to segment different adipose tissue
compartments (e.g., visceral vs. subcutaneous); fat
fraction and R2* maps were used to distinctly identify
brown adipose tissue depots. This approach is applicable
for finely-segmented quantitative volumetry of brown and
white adipose tissue depots.
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