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Abstract #3632

Multiparametric whole body MRI in castrate resistant prostate cancer bone metastases total tumour volume, ADC and fat fraction parameters reproducibility

Nina Tunariu 1,2 , David J Collins 1,2 , Matthew D Blackledge 1,2 , Mihaela Rata 1,2 , Julie Hughes 1 , Zaki Ahmad 1 , Raquel PerezLopez 1,2 , Amelia Altavilla 1,2 , Roberta Ferraldeschi 1,2 , Gerhardt Attard 1,2 , Johann S de Bono 1,2 , Martin O Leach 1,2 , and Dow-Mu Koh 1,2

1 The Royal Marsden NHS Foundation Trust, Sutton, London, United Kingdom, 2 The Institute of Cancer Research, Sutton, London, United Kingdom

More than 70% of castration-resistant prostate cancer patients have metastatic bone disease; the only available imaging response criteria are those of disease progression on bone scans, with no imaging criteria to positively assess therapy benefit. Diffusion weighted imaging (DWI) and fat fraction (FF) quantification are promising tools for detection and therapy monitoring of bone metastases. Currently, there are no published data documenting the reproducibility of total tumour volume (TTV) bone disease apparent diffusion coefficient (ADC) or FF values. The aim of this study was to document the reproducibility of TTV defined on DWI, ADC and FF using histograms methods.

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