Abstract #3632
Multiparametric whole body MRI in castrate resistant prostate cancer bone metastases total tumour volume, ADC and fat fraction parameters reproducibility
Nina Tunariu 1,2 , David J Collins 1,2 , Matthew D Blackledge 1,2 , Mihaela Rata 1,2 , Julie Hughes 1 , Zaki Ahmad 1 , Raquel PerezLopez 1,2 , Amelia Altavilla 1,2 , Roberta Ferraldeschi 1,2 , Gerhardt Attard 1,2 , Johann S de Bono 1,2 , Martin O Leach 1,2 , and Dow-Mu Koh 1,2
1
The Royal Marsden NHS Foundation Trust,
Sutton, London, United Kingdom,
2
The
Institute of Cancer Research, Sutton, London, United
Kingdom
More than 70% of castration-resistant prostate cancer
patients have metastatic bone disease; the only
available imaging response criteria are those of disease
progression on bone scans, with no imaging criteria to
positively assess therapy benefit. Diffusion weighted
imaging (DWI) and fat fraction (FF) quantification are
promising tools for detection and therapy monitoring of
bone metastases. Currently, there are no published data
documenting the reproducibility of total tumour volume
(TTV) bone disease apparent diffusion coefficient (ADC)
or FF values. The aim of this study was to document the
reproducibility of TTV defined on DWI, ADC and FF using
histograms methods.
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