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Abstract #3664

Feasibility of applying dual injection DCE-MRI technique in liver study

Amy Watkins 1 , Ka-Loh Li 1 , Xiaoping Zhu 1 , and Alan Jackson 1

1 Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom

Mapping kinetic parameters from DCE-MRI traditionally requires compromise in terms of spatial resolution, temporal resolution, and volume coverage. This study investigated feasibility of applying a dual injection DCE-MRI approach, which has been applied for brain tumor study, in liver. Combining information content from high temporal resolution (HTR) and high spatial resolution (HSR) data in liver produces a high quality HTR AIF, allowing kinetic mapping the HSR data with full liver coverage and a voxel size of 2 mm3. The low dose HTR data can also be advantageously used for kinetic analysis, e.g., providing more accurate bolus arrival time (BAT) maps.

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