Abstract #3688
Improved survival in a metastatic brain tumour model with combined focused ultrasound and targeted natural killer cells
Ryan Alkins 1,2 , Alison Burgess 1 , Milan Ganguly 1 , Giulio Francia 1 , Robert Kerbel 1,2 , Winfried S Wels 3 , and Kullervo Hynynen 1,2
1
Sunnybrook Research Institute, Toronto, ON,
Canada,
2
University
of Toronto, Toronto, ON, Canada,
3
Chemotherapeutisches
Forschungsinstitut Georg-Speyer-Haus, Frankfurt, Germany
Systemic treatments for breast cancer have limited
success treating brain metastasis due to the blood-brain
barrier (BBB). Here, we investigate the effects of
repeated delivery of targeted NK-92 cells to brain
metastases using MRI-guided focused ultrasound
(MRIgFUS). Our data demonstrate that MRIgFUS enhances
NK-92 cell translocation across the BBB. Repeated
MRIgFUS and NK-92 cell treatments lead to reductions in
tumour progression over time, particularly when the
treatments are applied early during tumour growth. These
data support the continued investigation of
MRIgFUS-mediated cell delivery as a potential treatment
option for metastatic brain tumours.
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