Abstract #3732
Examination of gradient-induced frequency drift on GABA-edited MRS
Ashley D Harris 1,2 , Benjamin Glaubitz 3 , Jamie Near 4 , C John Evans 5 , Nicolaas AJ Puts 1,2 , Tobias Schmidt-Wilcke 3 , Martin Tegenthoff 3 , Peter B Barker 1,2 , and Richard AE Edden 1,2
1
Russell H. Morgan Department of Radiology
and Radiological Science, Johns Hopkins University,
Baltimore, MD, United States,
2
F.M.
Kirby Research Centre, Kennedy Krieger Institute,
Baltimore, MD, United States,
3
Department
of Neurology, BG-Klinikum Bergmannsheil, Ruhr -
University, Bochum, Germany,
4
Douglas Mental
Health University Institute and Department of
Psychiatry, McGill University, Montreal, PQ, Canada,
5
CUBRIC,
School of Psychology, Cardiff University, Cardiff,
United Kingdom
The impact of gradient-induced frequency drift on
GABA-edited MRS that occurs after a typical fMRI was
assessed. Gradient-induced frequency drift has a
significant impact on measured GABA. The primary source
of measured GABA underestimation appears to be
subtraction artifacts, which can largely be corrected
with retrospective frequency correction.
Gradient-induced frequency drift causes reduced editing
efficiency of GABA but increased editing of
macromolecules; therefore, consideration of protocol
order or developing prospective frequency correction
should also be considered.
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