Comparison of N-Acetyl Aspartate and Polyethylene Glycol as Chemical Shift Reference Standards for Proton Magnetic Resonance Spectroscopic Thermometry

Use of the N-acetyl aspartate metabolite for temperature measurement in vitro has its disadvantages such as a spectral line overlap and peak inversion and its low viscosity can cause acquisition artifacts. This study demonstrates the novel use of polyethylene glycol as a proton nuclear magnetic resonance spectroscopy thermometry reference standard for phantom quantitative magnetic resonance imaging. The temperature dependent diffusion characteristics of polyethylene glycol can be adjusted by its inherent spectroscopic temperature reporting. Future work will develop polyethylene glycol for use in evaluating diffusion parameters and gradient performance in multicenter, longitudinal quantitative magnetic resonance imaging.

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