Abstract #3777
Increased Thalamic GABA and Decreased Glutamate-Glutamine in Chronic Manganese-exposed Metal Workers and Manganism Patients
Zaiyang Long 1,2 , Yue-Ming Jiang 3 , Xiang-Rong Li 4 , Jun Xu 2 , Chien-Lin Yeh 1,2 , Li-Ling Long 4 , Wei Zheng 1 , James B Murdoch 5 , and Ulrike Dydak 1,2
1
School of Health Sciences, Purdue
University, West Lafayette, IN, United States,
2
Department
of Radiology and Imaging Sciences, Indiana University
School of Medicine, Indianapolis, IN, United States,
3
Department
of Health Toxicology, Guangxi Medical University,
Nanning, Guangxi, China,
4
Department
of Radiology, The First Affiliated Hospital of Guangxi
Medical University, Nanning, Guangxi, China,
5
Toshiba
Medical Research Institute USA, Mayfield Village, OH,
United States
Metal workers chronically exposed to manganese (Mn) may
suffer from its neurotoxic effects, which may lead to
Parkinson-type symptoms. In a search for early signs of
Mn neurotoxicity, we investigated Mn accumulation in the
brain as well as changes in thalamic γ-aminobutyric acid
(GABA) and cortical glutamate levels in 39 metal
workers, 37 controls and 7 manganism patients.
Significantly decreased T1 values indicate Mn
accumulation in the workers brains. Significantly
elevated thalamic GABA levels in all, and decreased
glutamate levels in several of the groups may help
further elucidate the underlying mechanisms and serve as
early biomarkers of Mn neurotoxicity.
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