Abstract #3832

Evaluation of the novel SPIO GEH121333 for monitoring changes in tumor vascularity and vascular permeability after anti-angiogenic treatment using susceptibility contrast and T1-mapping

Else Marie Huuse ^1,2 , Jana Cebulla ² , Dan E Meyer ³ , Karina Langseth ⁴ , Siver Andre Moestue ² , and Tone Frost Bathen ²

¹ Department of medical Imaging, St. Olavs University Hospital, Trondheim, Norway, ² MI lab and Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, ³ Biomedical Imaging & Physiology Laboratory, GE Global Research Center, Niskayuna, NY, United States, ⁴ GE Healthcare AS, Oslo, Norway

Preclinical-phase iron oxide particles (GEH121333), with a relatively large diameter and a high r1/r2 rate was used for monitoring vascular response to bevacizumab treatment in ovarian xenografts. Changes in T2 and T2* relaxation rate was used for calculation marker for the blood vessel density Q= R2/( R2* ^2/3 ) and post contrast tissue T1 after clearance of iron particles from the blood pool was used as a measure for changed tumor vessel permeability. The results suggest that the novel GEH121333 particles can be used to detect vascular changes after anti-angiogenic therapy and that their magnetic properties allow evaluation of changes both in T1 and susceptibility imaging, attributable to underlying changes in permeability and blood vessel density, respectively.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.