Models of pulmonary vascular resistance in pulmonary hypertension from pulse wave analysis of MRI measurements in the main pulmonary artery
Angela Lungu 1 , Jim Wild 1 , Andy Swift 1 , David Capener 1 , David Kiely 2 , and Rod Hose 1
Cardiovascular Science, University of
Sheffield, Sheffield, South Yorkshire, United Kingdom,
Vascular Disease Unit, University of Sheffield,
Sheffield, South Yorkshire, United Kingdom
Pulmonary hypertension (PH) is a disease characterised
by increased mean pulmonary arterial pressure measured
by invasive right heart catheterisation. Temporally and
spatially registered images, from two separate MR
sequences (phase contrast and bSSFP) were acquired in
patients with suspected PH, and in healthy volunteers.
Anatomical and flow measurements were obtained
throughout the cardiac cycle. The computed waveforms
were combined with mathematical models (based on an
electrical impedance analogy and wave reflection
quantification) to assess the status of the pulmonary
circulation. Our results demonstrate that the proposed
method has the potential to non-invasively distinguish
between normal and clinically stratified PH groups.
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