Abstract #3890
Characterization of Cardiac Function in Nave Non-Human Primates Using Strain and Flow Based MRI Biomarkers: A Test-Retest Reproducibility and Inter-Animal Variability Study
Smita Sampath 1 , Michael Klimas 2 , Richard Baumgartner 3 , Dai Feng 3 , Elaine Manigbas 4 , Ai-Leng Liang 1 , Brian Henry 1 , Jeffrey L Evelhoch 2 , and Chih-Liang Chin 1
1
Translational Medicine Research Center,
Merck Sharp and Dohme, Singapore, Singapore, Singapore,
2
Imaging,
Merck & Co. Inc., West Point, Pennsylvania, United
States,
3
Biometric
Research, Biostatistics and Research Decision Sciences,
Merck & Co. Inc., Rahway, New Jersey, United States,
4
Imaging,
Maccine Pte. Ltd., Singapore, Singapore
Translational pre-clinical non-human primate (NHP)
models offer a unique framework to evaluate novel
therapeutics for human diseases. Herein, we characterize
cardiac function in NHPs using optimized MR tagging and
phase-contrast imaging on a 3T MRI scanner. Our results
describe regional strain and flow characteristics and
their temporal relationships during systolic pumping and
diastolic filling. We also demonstrate good
intra-subject reproducibility and acceptable
inter-subject variability in quantitative strain and
flow based imaging biomarkers. Prospective power
analyses support the future application of these
non-invasive functional biomarkers to evaluate
longitudinal changes in cardiac function during drug
safety or efficacy studies of experimental compounds.
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