Abstract #3894
Single Beat Approach to Left Ventricular Diastolic Chamber Stiffness Independent of Relaxation Time Constant Tau
Chun Schiros 1 , Thomas Denney 2 , Jose Tallaj 3 , Gilbert Perry 3 , Steven Lloyd 3 , Louis DellItalia 3 , and Himanshu Gupta 3
1
University of Alabama at Birmingham,
Birmingham, Alabama, United States,
2
Auburn
University, Alabama, United States,
3
University
of Alabama at Birmingham, Alabama, United States
Due to incomplete left ventricular (LV) relaxation,
relaxation time constant τ is used to correct for
minimum pressure in computing LV diastolic chamber
stiffness, an important diastolic parameter from single
beat. However, τ is affected by heart rate and
indirectly by LVEDP. Further, there are multiple
methodologies for calculating τ, resulting in various τ
values. Therefore, the corrected minimum pressure and
volume corresponding to 3.5τ, where LV is considered
completely relaxed, may not be always reliable. Here we
propose a novel single beat approach to corrected LV
diastolic chamber stiffness independent of τ utilizing
cMRI LV volumetric measurements.
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