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Abstract #3894

Single Beat Approach to Left Ventricular Diastolic Chamber Stiffness Independent of Relaxation Time Constant Tau

Chun Schiros 1 , Thomas Denney 2 , Jose Tallaj 3 , Gilbert Perry 3 , Steven Lloyd 3 , Louis DellItalia 3 , and Himanshu Gupta 3

1 University of Alabama at Birmingham, Birmingham, Alabama, United States, 2 Auburn University, Alabama, United States, 3 University of Alabama at Birmingham, Alabama, United States

Due to incomplete left ventricular (LV) relaxation, relaxation time constant τ is used to correct for minimum pressure in computing LV diastolic chamber stiffness, an important diastolic parameter from single beat. However, τ is affected by heart rate and indirectly by LVEDP. Further, there are multiple methodologies for calculating τ, resulting in various τ values. Therefore, the corrected minimum pressure and volume corresponding to 3.5τ, where LV is considered completely relaxed, may not be always reliable. Here we propose a novel single beat approach to corrected LV diastolic chamber stiffness independent of τ utilizing cMRI LV volumetric measurements.

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