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Abstract #3923

Optimal Sequence Weighting for 3D Dynamic Contrast Enhanced Imaging

Philip M Robson 1 , Claudia Calcagno 1 , Sarayu Ramachandran 1 , Mark E Lobatto 1 , Julia Witjes 1 , Venkatesh Mani 1 , and Zahi A Fayad 1

1 Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Three dimensional (3D) evaluation of atherosclerotic plaque is important for investigating vascular disease. Dynamic contrast enhanced (DCE) imaging is able to measure the abundant microvasculature in vulnerable plaque. However, it is challenging to achieve 3D coverage and adequate temporal resolution, therefore, it is important to optimize the available signal. Here, we compare the signal weighting and contrast to noise ratio of gradient-echo and spin-echo based 3D acquisition sequences in a phantom and assess image quality pre and post contrast agent administration in an atherosclerotic rabbit model. The optimal sequence was a turbo field echo acquisition with strong T1-weighting.

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