Abstract #3930
In vivo MR imaging of zebrafish with focus on cardiac tissue
Ilse van Herck 1 , Andor Veltien 1 , Juan Manuel Gonzlez-Rosa 2 , Erik de Vrieze 3 , Gert Flik 3 , Nadia Mercader 2 , and Arend Heerschap 1
1
Radiology, Radboudumc, Nijmegen,
Netherlands,
2
Cardiovascular
development and repair, CNIC, Madrid, Spain,
3
Organismal
animal physiology, Radboud University Nijmegen,
Nijmegen, Netherlands
Zebrafish have become popular models to study disease
conditions such as myocardial infarctions. For cardiac
investigations it is important that heart function can
be assessed by live imaging, but this is challenging in
adult zebrafish. We developed an experimental setup that
allowed to acquire MRI of live zebrafish with limited
motion artifacts and an in-plane resolution of 25x25 m.
In addition we obtained in vivo cardiac MR images of the
zebrafish heart using the IntraGate brightblood Cine
FLASH sequence.
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