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Abstract #3930

In vivo MR imaging of zebrafish with focus on cardiac tissue

Ilse van Herck 1 , Andor Veltien 1 , Juan Manuel Gonzlez-Rosa 2 , Erik de Vrieze 3 , Gert Flik 3 , Nadia Mercader 2 , and Arend Heerschap 1

1 Radiology, Radboudumc, Nijmegen, Netherlands, 2 Cardiovascular development and repair, CNIC, Madrid, Spain, 3 Organismal animal physiology, Radboud University Nijmegen, Nijmegen, Netherlands

Zebrafish have become popular models to study disease conditions such as myocardial infarctions. For cardiac investigations it is important that heart function can be assessed by live imaging, but this is challenging in adult zebrafish. We developed an experimental setup that allowed to acquire MRI of live zebrafish with limited motion artifacts and an in-plane resolution of 25x25 m. In addition we obtained in vivo cardiac MR images of the zebrafish heart using the IntraGate brightblood Cine FLASH sequence.

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