Compartmentation in the Myocardium: On the Fate of Exogenous Versus Glycolytically Derived Pyruvate

Depending upon the underlying energetic demands for ATP production in the myocardium, pyruvate has multiple metabolic fates: exchanging with alanine or lactate, being oxidized via the pyruvate dehydrogenase (PDH) complex, or carboxylated to form oxaloacetate. Here the metabolism of exogenous hyperpolarized [1- ¹³ C]pyruvate is compared with that of glucose in the perfused mouse heart. A battery of analyses indicate that 1)exogenous pyruvate oxidation and glucose oxidation are not synonymous, 2)hyperpolarized lactate production does not necessarily report on [lactate] in the heart, and 3) propionate activated PDH flux even in the presence of a short chain fatty acid. The simplest interpretation of these phenomena requires a two compartment model of myocardial metabolism.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.