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Abstract #3952

Prognostic CMR parameters for heart failure and arrhythmias in large cohort of well treated thalassemia major patients

Antonella Meloni 1 , Vincenzo Positano 1 , Giuseppe Rossi 2 , Petra Keilberg 1 , Silvia Macchi 3 , Antonella Carollo 4 , Valentina Vinci 5 , Paolo Preziosi 6 , Cristina Salvatori 1 , Massimo Lombardi 1 , and Alessia Pepe 1

1 CMR Unit, Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology, Pisa, Italy, 2 Epidemiology and Biostatistics Unit, Institute of Clinical Physiology, CNR, Pisa, Italy, 3 Servizio Trasfusionale, Ospedale Santa Maria delle Croci, Ravenna, Italy, 4 Servizio Talassemia-U.O. Pediatria Talassemia, Az. Osp. "Sant'Antonio abate", Trapani, Italy, 5 Istituto di Radiologia, Az. Osp. "Garibaldi" Presidio Ospedaliero Nesima, Catania, Italy, 6 U.O.C. Diagnostica per Immagini e Interventistica, Policlinico Casilino", Roma, Italy

This study aimed to determine the predictive value of CMR parameters for heart failure and arrhythmias in thalassemia major. Thanks to a MR-guided, patient-specific adjustment of the chelation therapy, few cardiac events were detected. Severe and homogeneous MIO, myocardial fibrosis and ventricular dysfunction identify patients at high risk of heart failure. Heart T2* doesnt have any power in predicting arrhythmias while male sex and atrial dilation are independent prognosticators.

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