Non-contrast MRI characterization of thrombus composition and susceptibility to thrombolysis in a mouse model of deep vein thrombosis.
Marcelo E Andia 1 , Alkystis Phininkaridou 2 , Prakash Saha 3 , Bijan Modarai 3 , Alberto Smith 3 , and Rene M Botnar 2
Radiology Deparment, Pontificia Universidad
Catolica de Chile, Santiago, Santiago, Chile,
of Imaging Sciences and Biomedical Engineering, Kings
College London, London, United Kingdom,
Department of Surgery, Kings College London, London,
In vivo evaluation of the stage of organization of
venous thrombosis could help guide medical treatment and
intervention. We have previously demonstrated that
magnetization transfer ratio (MTR), T1 mapping and
apparent diffusion coefficient (ADC) sequences detect
the concentration and spatial distribution of collagen
and methemoglobin, and proton diffusivity of the
thrombus, respectively. In this work we studied if these
MR parameters could improve the identification of
thrombus suitable for thrombolytic treatment.
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