Abstract #3958
Area at risk identified by T2 mapping is influenced by the severity of the initial ischemic insult in acute myocardial infarction
Nilesh R Ghugre 1,2 , Reuben Thomas 3,4 , Kevin Thai 1 , Jennifer Barry 1 , Beiping Qiang 3 , Bradley H Strauss 3,5 , and Graham A Wright 1,6
1
Physical Sciences Platform, Sunnybrook
Research Institute, Toronto, ON, Canada,
2
Department
of Medical Biophysics, University of Toronto, Toronto,
ON, Canada,
3
Biological
Sciences Platform, Sunnybrook Research Institute,
Toronto, ON, Canada,
4
Department
of Laboratory Medicine and Pathobiology, University of
Toronto, ON, Canada,
5
Schulich
Heart Research Program, Sunnybrook Health Sciences
Centre, ON, Canada,
6
Department
of Medical Biophysics, University of Toronto, ON, Canada
Recent studies have demonstrated that an elevated T2
signal can delineate the area at risk (AAR) post acute
myocardial infarction. However, it has been questioned
whether the T2 elevation simply identifies the infarcted
myocardium rather than the true AAR and whether edema is
indeed present in the salvageable region. The purpose of
the study was to assess whether T2-based AAR is
influenced by the severity of myocardial injury,
particularly by microvascular obstruction. Our study
demonstrates that assessment of AAR by T2 is affected by
the degree of myocardial damage, suggesting that edema
extent may be modulated by infarct size.
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